The pathophysiology of pure red cell aplasia: implications for therapy

The pathophysiology of pure red cell aplasia: implications for therapy.

To determine the utility of marrow culture in defining the natural history and therapeutic response of pure red cell aplasia we have studied 37 patients. Patients were evaluated at the University of Washington before specific therapies (n = 21) or at the time of treatment failure in = 16). Evaluation included a medical and drug exposure history, a physical examination, a chest x-ray or computed...

Acquired pure red cell aplasia.

Correspondence MEDICALTJOSRNAL 559 Acquired Pure Red Cell Aplasia SIR,-May we make the following observation about your article on acquired pure red cell aplasia and its treatment with steroids (6 April, p. 3) ? A pure red cell aplasia that responded to riboflavine or prednisone has been described in African adults and in children with marasmus and kwashiorkor.' In marasmus and kwashiorkor an e...

Cyclosporine for pure red cell aplasia.

Pure Red Cell Aplasia Following Interleukin-2 Therapy.

A 61-year-old woman with metastatic renal cell carcinoma underwent systemic treatment with high-dose interleukin-2 (IL-2). Anemia requiring transfusion of 1 unit of packed red blood cells (PRBCs) was required during the second week of IL-2 therapy. One month following completion of high-dose IL-2 treatment, she was hospitalized for severe, symptomatic anemia and received 5 units of PRBCs. She w...

Studies on Pure Red Cell Aplasia

An 1 8-yr-old female with chronic active The patient’s plasma was cytotoxic for hepatitis developed a severe anemia due erythroblasts. Following splenectomy, a to a lack of red cell production. Her bane remission of the disease occurred. This marrow showed many large proerythrostudy indicates that in some cases the blasts but an almost complete lack of more anemia associated with abundant marro...